Porous tantalum biocomposites for osteochondral defect repair
نویسندگان
چکیده
منابع مشابه
Porous tantalum biocomposites for osteochondral defect repair
OBJECTIVES We sought to determine if a durable bilayer implant composed of trabecular metal with autologous periosteum on top would be suitable to reconstitute large osteochondral defects. This design would allow for secure implant fixation, subsequent integration and remodeling. MATERIALS AND METHODS Adult sheep were randomly assigned to one of three groups (n = 8/group): 1. trabecular metal...
متن کاملBiomimetic biphasic scaffolds for osteochondral defect repair
The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structure...
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For centuries, inflammatory/foreign body reactions have plagued the attempts of clinicians to use metals for tissue and bone reconstructions. Since corrosion contributes to the rejection of metal by the body, an extremely bioinert metal - tantalum - has been successfully used in medicine. The outstanding biocompatibility and flexibility of tantalum established the basis for a growing cadre of c...
متن کاملBone Marrow Aspiration Concentrate and Platelet Rich Plasma for Osteochondral Repair in a Porcine Osteochondral Defect Model
BACKGROUND Bone marrow aspiration concentrate (BMAC) may possess a high potency for cartilage and osseous defect healing because it contains stem cells and multiple growth factors. Alternatively, platelet rich plasma (PRP), which contains a cocktail of multiple growth factors released from enriched activated thrombocytes may potentially stimulate the mesenchymal stem cells (MSCs) in bone marrow...
متن کاملDesign and Characterisation of a Multi-Layered Collagen-Based Scaffold for Osteochondral Defect Repair
Introduction Articular cartilage is a highly specialised tissue which is organised into distinct layers that vary in both structure and composition according to distance from the surface. Cartilage has a poor ability to regenerate itself and as a result, superficial damage almost inevitably leads to the development of osteoarthritis (OA). Recently, the potential of osteochondral tissue engineer...
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ژورنال
عنوان ژورنال: Bone & Joint Research
سال: 2016
ISSN: 2046-3758
DOI: 10.1302/2046-3758.59.bjr-2016-0070.r1